R: Metformin

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Anti-Aging Human Study on Metformin Wins FDA Approval

March 2016

Metformin’s Primary Anti-Aging Mechanism
Metformin enhances the activity of an enzyme found within our cells called adenosine monophosphate-activated protein kinase—or AMPK for short. AMPK activation helps mimic the beneficial effects of calorie restriction, the best documented method of slowing and reversing biomarkers of human aging.

http://www.lifeextension.com/magazine/2016/3/anti-aging-human-study-on-metformin-wins-fda-approval/page-01

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